A potential therapy against SARS-CoV-2 could aim at interfering with the binding of the S- protein to ACE2, thereby preventing the virus from entering our cells. This could be achieved by designing small peptides that can bind to the S-protein. During an active SARS-CoV-2 infection, these small peptides would bind the viral particle hiding the part of the S-protein that interacts with ACE2, effectively limiting the number of infected cells and slowing down the infection.