Entry |
Solvent |
Equiv of rongalite |
Temp (°C) |
Yield
(%)b
|
1 |
DMF |
2 |
80 |
13 |
2 |
DMSO |
2 |
80 |
20 |
3 |
NMP |
2 |
80 |
Trace |
4 |
CH3CN |
2 |
80 |
Trace |
5 |
THF |
2 |
80 |
11 |
6 |
DMSO |
3 |
80 |
57 |
7 |
DMSO |
4 |
80 |
68 |
8 |
DMSO |
5 |
80 |
65 |
9 |
DMSO |
4 |
70 |
60 |
10 |
DMSO |
4 |
90 |
75 |
11 |
DMSO |
4 |
100 |
74 |
12c
|
DMSO |
4 |
90 |
82 |
13d
|
DMSO |
4 |
90 |
79 |
14e
|
DMSO |
4 |
90 |
84 |
15e,f
|
DMSO |
4 |
90 |
81 |
16e
|
DMSO |
0 |
90 |
N.D. |