General procedure for the rongalite-mediated allylic defluorination reductive cross-coupling
A 25 mL Schlenk-type tube (with a Teflon screw cap and a side arm) equipped with a magnetic stir bar was charged with the mixture of CF3-alkene 1 (0.20 mmol), diaryliodonium salt 2 (0.40 mmol), rongalite (0.80 mmol), and DMSO (2.0 mL), the mixture was stirred at 90 °C (metal heating block) for 3 hours under argon atomosphere. After cooling to room temperature, the mixture was quenched with water (25 mL), extracted with EtOAc (3 × 50 mL), the combined organic layers were washed with brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was purified by column chromatography on silica gel (eluent: PE/EA) to afford the corresponding products.
Supporting Information
The supporting information for this article is available on the WWW under https://doi.org/10.1002/cjoc.2023xxxxx.
Acknowledgement
This work was supported by the National Natural Science Foundation of China (Grants 21971080, 21971079, 21772051). This work was also supported by the 111 Project B17019.
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