General procedure for the rongalite-mediated allylic
defluorination reductive cross-coupling
A 25 mL Schlenk-type tube (with a Teflon screw cap and a side arm)
equipped with a magnetic stir bar was charged with the mixture of
CF3-alkene 1 (0.20 mmol), diaryliodonium salt 2 (0.40
mmol), rongalite (0.80 mmol), and DMSO (2.0 mL), the mixture was stirred
at 90 °C (metal heating block) for 3 hours under argon atomosphere.
After cooling to room temperature, the mixture was quenched with water
(25 mL), extracted with EtOAc (3 × 50 mL), the combined organic layers
were washed with brine, dried over anhydrous
Na2SO4 and concentrated under reduced
pressure. The crude product was purified by column chromatography on
silica gel (eluent: PE/EA) to afford the corresponding products.
Supporting Information
The supporting information for this article is available on the WWW
under https://doi.org/10.1002/cjoc.2023xxxxx.
Acknowledgement
This work was supported by the National Natural Science Foundation of
China (Grants 21971080, 21971079, 21772051). This work was also
supported by the 111 Project B17019.
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