New recognition of heart-brain axis and its implication in the
pathogenesis and treatment of PTSD
Abstract
Post-traumatic stress disorder (PTSD) is a complex psychological
disorder provoked by distressing experiences, and it remains without
highly effective intervention strategies. The exploration of PTSD’s
underlying mechanisms is crucial for advancing diagnostic and
therapeutic approaches. Current studies primarily explore PTSD through
the lens of the CNS, investigating concrete molecular alterations in the
cerebral area and neural circuit irregularities. However, the body’s
response to external stressors, particularly the changes in
cardiovascular function, is often pronounced, evidenced by notable
cardiac dysfunction. Consequently, examining PTSD with a focus on
cardiac function is vital for the early prevention and targeted
management of the disorder. This review undertakes a comprehensive
literature analysis to detail the alterations in brain and heart
structures and functions associated with PTSD. It also synthesizes
potential mechanisms of heart-brain axis interactions relevant to PTSD’s
development. Ultimately, by considering cardiac function, this review
proposes novel perspectives for PTSD’s prophylaxis and therapy.